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    Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Diffuse axonal injury is an extremely common type of traumatic brain injury encountered in motor vehicle crashes, sports injuries, and in combat. Although many cases of diffuse axonal injury result in chronic disability, there are no current treatments for this condition.
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    A human xenograft model for testing early events of epithelial neoplastic invasion

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    Animal models and molecular imaging tools to investigate lymph node metastases

    We report on a model of human prostate tumor cell invasion using the SCID severe combined immunodeficient mouse diaphragm. Tumor cells were injected into SCID mice intraperitoneally and the diaphragms harvested three to five weeks later. Electron microscopy showed tumor cell penetration of the mesothelial cell layer and adhesion to the underlying basement membrane on the inferior surface of the mouse diaphragm, where colonies developed. Immunohistochemistry showed invasion by tumor cells through the basement membrane into the muscle of the diaphragm, presence of human tumor cells among the muscle cells and the presence of selected proteins on the invasion front of the tumor cells. Digital image analysis enabled quantitative comparison of events in the metastatic cascade by variants of the tumor cell line and evaluation of the effectiveness of a putative tumor inhibitor. Results suggest that the SCID mouse diaphragm model is a convenient, effective, easily oriented and reproducible in vivo model of the early events associated with human prostate tumor cell invasion.
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    Allergic contact dermatitis ACD and its animal model, contact hypersensitivity CHS , are T cell-mediated delayed-type hypersensitivity reactions caused by sensitization and secondary epicutaneous exposure elicitation or challenge to contact allergens e. A flare-up or retest reaction of ACD often occurs on previously affected sites 4 , 5. In guinea pigs, inflammation in a CHS-healed region was found to be more severe than that in the previously unaffected region in the same individual upon re-exposure to the same hapten 6.
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    Lymph node metastasis is a strong predictor of poor outcome in cancer patients. Animal studies of lymph node metastasis are constrained by difficulties in the establishment of appropriate animal models, limitations in the noninvasive monitoring of lymph node metastasis progression, and challenges in the pathologic confirmation of lymph node metastases. In this comprehensive review, we summarize available preclinical animal cancer models for noninvasive imaging and identification of lymph node metastases of non-hematogenous cancers. Furthermore, we discuss the strengths and weaknesses of common noninvasive imaging modalities used to identify tumor-bearing lymph nodes and provide guidelines for their pathological confirmation. Lymphatic metastasis is a predictor of poor outcome in many solid malignancies [ 1 — 4 ].
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