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Effexor and sperm count

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    Language: English French. Question Some of my male patients who are taking antidepressants are planning to become fathers. Do selective serotonin reuptake inhibitors SSRIs affect sperm, causing either decreased fertility or increased risk of congenital anomalies? Answer There is limited evidence regarding paternal SSRI use before conception and its effects on reproductive outcomes; however, there might be some increased risk of subfertility based on animal studies and sperm-quality studies. There are insufficient data at this time to change prescribing practices of SSRIs in men who are hoping to become fathers.
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    Effect of Venlafaxine, Pramipexole, and Valsartan on Spermatogenesis in Male Rats | ACS Omega

    This study goes one step further, demonstrating that they can cause a major increase in genetic damage to sperm," says Dr. Peter Schlegel, the study's senior author. These men should talk with their physician about their treatment options, including non-SSRI depression medications. The study followed 35 healthy male volunteers who were given paroxetine, a selective serotonin reuptake inhibitor SSRI , for five weeks.
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    Effects of selective serotonin reuptake inhibitors on sperm and male fertility

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    Semen quality decreased but became normal after discontinuing drugs. Tanrikut presented case reports on two patients who had a clear relationship between antidepressant use and infertility. The first case was a year old man with a seven-month history of primary infertility. His physical and urologic examinations were unremarkable. A repeat analysis four weeks after discontinuation of citalopram showed a return to normal of all parameters.
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